CAS编号 | 2138442-31-4 |
抗体名 | Plamotamab (帕拉莫妥单抗 ) |
靶点 | CD3E/MS4A1[Homo sapiens] |
纯度 | % |
产地 | 中国 |
品牌 | Chemstan |
货号 | CSD00605 |
保存条件 | store at -80℃ |
抗原来源 | CHO cells |
保质期 | 一年 |
规格 | 100μg |
产品用途 | 仅用于科研用途 |
浓度 | 95% |
是否进口 | 否 |
货号(Catalog No.)
CSD00605
通用名INN
Plamotamab
纯度(Purity)
>95%
浓度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
CHO cells
内毒素(Endotoxin level)
Please contact with the lab for this information.
生物活性
产品描述(Description)
Plamotamab (XmAb13676) is a tumor-targeted antibody that contains both a CD20 binding domain and a cytotoxic T-cell binding domain (CD3).An XmAb Bispecific Fc domain serves as the scaffold for these two antigen binding domains and confers long circulating half-life,stability and ease of manufacture on plamotamab.CD20 is highly expressed on B-cell tumor cells, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) cells.Engagement of CD3 by plamotamab activates T cells for highly potent and targeted killing of CD20-expressing tumor cells. The structural stability and modularity enabled by the XmAb Bispecific Fc domain allowed the tuning of plamotamab’s potency to balance anti-tumor activity with the reduction of immune toxicity that can result from T-cell activation.
别名(Alternative names)
XmAb-13676
靶点;物种(Specificity target name;species)
CD3E/MS4A1[Homo sapiens]
种类(Species)
Chimeric,Humanized
受体鉴定(Receptor identification)
IgG1-kappa / scFv-h-CH2-CH3
化学信息
CAS
2138442-31-4
存储条件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .
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