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Recombinant Human ITGB1 protein
  • 品牌:chemstan
  • 产地:中国
  • 货号:CSP00098
  • 价格: ¥1280/支
  • 发布日期: 2020-11-04
  • 更新日期: 2024-03-27
产品详请
产地 中国
品牌 chemstan
货号 CSP00098
用途范围 科研实验
纯度 >90%
规格 50ug
是否进口

概述(Summary)icon

英文全称

Recombinant Human ITGB1 protein

纯度(Purity)

>90% as determined by SDS-PAGE

内毒素(Endotoxin level)

Please contact with the lab for this information.

蛋白构建(Construction)

A DNA sequence encoding the human ITGB1 (Gln21-Asp728) was fused with His tag

Accession #

P05556

表达宿主(Host)

E.coli

种属(Species)

Homo sapiens (Human)

预测分子量(Predicted Molecular Mass)

75.93 kDa

制剂(Formulation)

Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.

运输方式(Shipping)

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存(Stability &Storage)

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶(Reconstitution)

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

背景(Background)icon

背景介绍

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion

分子别名(Alternative Names)

Integrin beta-1,Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta,CD29.


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