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Recombinant Human MMP1 protein
  • 品牌:chemstan
  • 产地:中国
  • 货号:CSP00108
  • 价格: ¥1280/支
  • 发布日期: 2020-11-04
  • 更新日期: 2024-03-27
产品详请
产地 中国
品牌 chemstan
货号 CSP00108
用途范围 科研实验
纯度 >90%
规格 50ug
是否进口

概述(Summary)icon

英文全称

Recombinant Human MMP1 protein

纯度(Purity)

>90% as determined by SDS-PAGE

内毒素(Endotoxin level)

Please contact with the lab for this information.

蛋白构建(Construction)

A DNA sequence encoding the human MMP1 (Phe20-Asn469) was fused with His tag

Accession #

P03956

表达宿主(Host)

E.coli

种属(Species)

Homo sapiens (Human)

预测分子量(Predicted Molecular Mass)

51.77 kDa

制剂(Formulation)

Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.

运输方式(Shipping)

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存(Stability &Storage)

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶(Reconstitution)

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

背景(Background)icon

背景介绍

MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

分子别名(Alternative Names)

Interstitial collagenase,Fibroblast collagenase,Matrix metalloproteinase-1,MMP-1,22 kDa interstitial collagenase,27 kDa interstitial collagenase.


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