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Recombinant Human IL18R1 protein
  • 品牌:chemstan
  • 产地:中国
  • 货号:CSP00792
  • 价格: ¥1280/支
  • 发布日期: 2020-11-04
  • 更新日期: 2024-03-27
产品详请
产地 中国
品牌 chemstan
货号 CSP00792
用途范围 科研实验
纯度 >90%
规格 50ug
是否进口

概述(Summary)icon

英文全称

Recombinant Human IL18R1 protein

纯度(Purity)

>90% as determined by SDS-PAGE

内毒素(Endotoxin level)

Please contact with the lab for this information.

蛋白构建(Construction)

A DNA sequence encoding the human IL18R1 (Thr147-Asn255) was fused with His tag

Accession #

Q13478

表达宿主(Host)

E.coli

种属(Species)

Homo sapiens (Human)

预测分子量(Predicted Molecular Mass)

14.02 kDa

制剂(Formulation)

Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.

运输方式(Shipping)

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存(Stability &Storage)

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶(Reconstitution)

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

背景(Background)icon

背景介绍

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

分子别名(Alternative Names)

Interleukin-18 receptor 1,IL-18R-1,IL-18R1,CD218 antigen-like family member A,CDw218a,IL1 receptor-related protein,IL-1Rrp,IL1R-rp,Interleukin-18 receptor alpha,IL-18R-alpha,IL-18Ralpha,CD218a.

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