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Recombinant Human LXN protein
  • 品牌:chemstan
  • 产地:中国
  • 货号:CSP01018
  • 价格: ¥1280/支
  • 发布日期: 2020-11-04
  • 更新日期: 2024-03-27
产品详请
产地 中国
品牌 chemstan
货号 CSP01018
用途范围 科研实验
纯度 >90%
规格 50ug
是否进口

概述(Summary)icon

英文全称

Recombinant Human LXN protein

纯度(Purity)

>90% as determined by SDS-PAGE

内毒素(Endotoxin level)

Please contact with the lab for this information.

蛋白构建(Construction)

A DNA sequence encoding the human LXN (Met1-Glu222) was fused with His tag

Accession #

Q9BS40

表达宿主(Host)

E.coli

种属(Species)

Homo sapiens (Human)

预测分子量(Predicted Molecular Mass)

26.22 kDa

制剂(Formulation)

Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.

运输方式(Shipping)

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

稳定性&储存(Stability &Storage)

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

复溶(Reconstitution)

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

背景(Background)icon

背景介绍

Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to theprotease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.

分子别名(Alternative Names)

Latexin,Endogenous carboxypeptidase inhibitor,ECI,Protein MUM,Tissue carboxypeptidase inhibitor,TCI.


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