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首页 > 产品展厅 > 抗体 Antibody  > 司库奴单抗 (Secukinumab)

司库奴单抗 (Secukinumab)
起批量( 价格
≥1 ¥100元/支
  • 供货能力:100
  • 最低订购量:1支
  • 可销售总数量:100支
  • 建议零销价:100元/支
  • 发布日期: 2020-12-14
  • 更新日期: 2020-12-14
产品详细说明
抗体名: Secukinumab 浓度: 1mg/ml %
靶点: 宿主:
用途范围: 科研实验 应用范围:
纯度: 95% HPLC % 产地: 中国
品牌: chemstan 货号: CSD00222
产品用途: 科研实验 亚型:
是否单克隆: 免疫原:
保质期: -20°C/1 year CAS编号: 1229022-83-6
标记物: 规格: 100mg
抗原来源: 适应物种:
克隆性: 标识物:
形态: 保存条件: store at -80°C
是否进口:

货号(Catalog No.)icon

ATAD00222

通用名INNicon

Secukinumab

纯度(Purity)icon

>95%

浓度( Concentration)icon

1mg/ml

Formulationicon

PBS buffer pH7.5

Sourceicon

CHO cells

内毒素(Endotoxin level)icon

Please contact with the lab for this information.

生物活性icon

产品描述(Description)

Secukinumab (Cosentyx) is a human monoclonal antibody designed for the treatment of uveitis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. Secukinumab is an interleukin-17A (IL-17A) inhibitor marketed by Novartis. IL-17 is a group of proinflammatory cytokines released by cells of the immune system and and exist in higher levels in many immune conditions associated with chronic inflammation. By targeting IL-17A, secukinumab has shown excellent efficacy in psoriasis by normalizing skin histology and was approved by the United States Food and Drug Administration on January 21, 2015 to treat adults with moderate-to-severe plaque psoriasis.

别名(Alternative names)

AIN457

靶点;物种(Specificity target name;species)

IL17A[Homo sapiens]

活性研究(体外/体内研究)(Activity in vitro)

Compound AX-024 hydrochloride is >10,000-fold more potent than the AX-000 hit in terms of inhibition of TCR-triggered T cell proliferation. The IC50 of AX-024 hydrochloride in this assay is 1 nM, although it shows inhibitory effects at a concentration of 1 pM or less. AX-024 hydrochloride is also a much more potent inhibitor of cytokine release by human peripheral blood mononuclear cells stimulated with anti-CD3 than AX-000, strongly hindering interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10, and IL-17A production at a concentration of 10 nM. In CD8+ T cells of OT1 TCR transgenic (OT1Tg) mice bearing wild-type (WT) AX-024 hydrochloride strongly inhibits T cell proliferation at a concentration of 0.1 nM when OT1Tg T cells are WT for the PRS mutation. Coimmunoprecipitation experiments in these cells show that Nck recruitment to the TCR is induced upon stimulation in the absence of drug but is inhibited in the presence of AX-024 hydrochloride in a dose-dependent manner at concentrations starting from 1 nM.

种类(Species)

Homo sapiens

受体鉴定(Receptor identification)

IgG1-kappa

化学信息icon

分子量(MV)


147940.0 Da

CAS


1229022-83-6

存储条件(Storage)

store at -80°C



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