15926423062  

产品展厅

Research Grade Secukinumab(司库奴单抗 )
  • 品牌:chemstan
  • 产地:中国
  • 型号:100mg
  • 货号:CSD00222
  • cas:1229022-83-6
  • 价格: ¥2480/支
  • 发布日期: 2020-12-14
  • 更新日期: 2024-03-27
产品详请
CAS编号 1229022-83-6
抗体名 Secukinumab
用途范围 科研实验
纯度 95% HPLC%
产地 中国
品牌 chemstan
货号 CSD00222
保存条件 store at -80°C
保质期 -20°C/1 year
规格 100mg
产品用途 科研实验
浓度 1mg/ml%
是否进口

货号(Catalog No.)

CSD00222

通用名INN

Secukinumab

纯度(Purity)

>95%

浓度( Concentration)

1mg/ml

Formulation

PBS buffer pH7.5

Source

CHO cells

内毒素(Endotoxin level)

Please contact with the lab for this information.

生物活性

产品描述(Description)

Secukinumab (Cosentyx) is a human monoclonal antibody designed for the treatment of uveitis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. Secukinumab is an interleukin-17A (IL-17A) inhibitor marketed by Novartis. IL-17 is a group of proinflammatory cytokines released by cells of the immune system and and exist in higher levels in many immune conditions associated with chronic inflammation. By targeting IL-17A, secukinumab has shown excellent efficacy in psoriasis by normalizing skin histology and was approved by the United States Food and Drug Administration on January 21, 2015 to treat a.dults with moderate-to-severe plaque psoriasis.

别名(Alternative names)

AIN457

靶点;物种(Specificity target name;species)

IL17A[Homo sapiens]

活性研究(体外/体内研究)(Activity in vitro)

Compound AX-024 hydrochloride is >10,000-fold more potent than the AX-000 hit in terms of inhibition of TCR-triggered T cell proliferation. The IC50 of AX-024 hydrochloride in this assay is 1 nM, although it shows inhibitory effects at a concentration of 1 pM or less. AX-024 hydrochloride is also a much more potent inhibitor of cytokine release by human peripheral blood mononuclear cells stimulated with anti-CD3 than AX-000, strongly hindering interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10, and IL-17A production at a concentration of 10 nM. In CD8+ T cells of OT1 TCR transgenic (OT1Tg) mice bearing wild-type (WT) AX-024 hydrochloride strongly inhibits T cell proliferation at a concentration of 0.1 nM when OT1Tg T cells are WT for the PRS mutation. Coimmunoprecipitation experiments in these cells show that Nck recruitment to the TCR is induced upon stimulation in the absence of drug but is inhibited in the presence of AX-024 hydrochloride in a dose-dependent manner at concentrations starting from 1 nM.

种类(Species)

Homo sapiens

受体鉴定(Receptor identification)

IgG1-kappa

化学信息

分子量(MV)

147940.0 Da

CAS:1229022-83-6

存储条件(Storage)

store at -80°C

Note
For research use only. Not suitable for clinical or therapeutic use.

< 返回前一个页面 >





联系方式
手机:15926423062
手机访问官网

15926423062

武汉科斯坦生物科技有限公司 版权所有(C)2024  XML 技术支持: 盖德化工网   食品商务网  

武汉科斯坦生物科技有限公司