产地 | 中国 |
品牌 | chemstan |
货号 | CS-108355 |
用途范围 | 科研 |
英文名称 | R59949 |
纯度 | % |
CAS编号 | 120166-69-0 |
规格 | 100 mg |
分子式 | C??H??F?N?OS |
是否进口 | 否 |
Description | R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol[1] [2] [3] . |
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In Vitro | In the presence of R59949, vasopressin- as well as collagen-induced release reaction and aggregation was strongly increased, independently of the formation of arachidonate metabolites[1] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
Molecular Weight | 489.58 |
Formula | C??H??F?N?OS |
CAS No. | 120166-69-0 |
SMILES | O=C1N(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=C(F)C=C4)C(NC5=C1C=CC=C5)=S |
Shipping | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
References |
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15926423062
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