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cis-Mulberroside A
  • 品牌:chemstan
  • 产地:中国
  • 货号:CS-N0619A
  • cas:166734-06-1
  • 价格: ¥600/mg
  • 发布日期: 2020-12-29
  • 更新日期: 2024-03-27
产品详请
产地 中国
品牌 chemstan
货号 CS-N0619A
用途范围 科研
英文名称 cis-Mulberroside A
纯度 %
CAS编号 166734-06-1
规格 100 mg
分子式 C??H??O??
是否进口
Description

cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.)[1] . Mulberroside A decreases the expressions of TNF-αIL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects[2] . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM[3] .

In Vivo

Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:Male Kun-Ming mice (20±2 g)[4]Dosage:5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weightAdministration:Orally initiated at 9:00 a.m.Result:10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.

Molecular Weight

568.52

Formula

C??H??O??

CAS No.

166734-06-1

SMILES

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC(/C=C\C3=C(C=C(C=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O)=CC(O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • [1]. Mei M, et al. In vitro pharmacokinetic characterization of mulberroside A, the main polyhydroxylated stilbene in mulberry (Morus alba L.), and its bacterial metabolite oxyresveratrol in traditional oral use. J Agric Food Chem. 2012 Mar 7;60(9):2299-308.

    [2]. Wang CP, et al. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res. 2014 Jul;92(7):944-54.

    [3]. Kim JK, et al. Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition. J Ind Microbiol Biotechnol. 2010 Jun;37(6):631-7.

    [4]. Cai-Ping Wang,et al. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 2011 May;77(8):786-94.


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