产地 | 中国 |
品牌 | chemstan |
货号 | CS-N0619A |
用途范围 | 科研 |
英文名称 | cis-Mulberroside A |
纯度 | % |
CAS编号 | 166734-06-1 |
规格 | 100 mg |
分子式 | C??H??O?? |
是否进口 | 否 |
Description | cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.)[1] . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects[2] . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM[3] . |
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In Vivo | Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice[4] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:Male Kun-Ming mice (20±2 g)[4]Dosage:5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weightAdministration:Orally initiated at 9:00 a.m.Result:10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal. |
Molecular Weight | 568.52 |
Formula | C??H??O?? |
CAS No. | 166734-06-1 |
SMILES | OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC(/C=C\C3=C(C=C(C=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O)=CC(O)=C2 |
Shipping | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
References |
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15926423062
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