产地 | 中国 |
品牌 | Targetmol |
货号 | T3148 |
用途范围 | 对照品 |
纯度 | 98%% |
CAS编号 | 115103-85-0 |
规格 | 2mg |
是否进口 | 否 |
MK-571 is a selective, orally active?antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK571 can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK571 significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
常用名 | MK-571钠盐 | 英文名 | MK-571 |
---|---|---|---|
CAS号 | 115103-85-0 | 分子量 | 537.069 |
密度 | N/A | 沸点 | N/A |
分子式 | C26H26ClN2NaO3S2 | 熔点 | N/A |
MSDS | N/A | 闪点 | N/A |
MK-571 sodium salt是一种选择性,口服活性的白三烯D4受体拮抗剂,在豚鼠和人肺膜的Ki分别为0.22 和 2.1 nM。
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