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2',3'-cGAMP用途:

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是一种哺乳动物细胞中的内源性 cGAMP 分子，其含有两个不同的磷酸二酯键，一个位于 GMP 的 2'-OH 和 AMP 的 5'-磷酸之间，另一个位于 AMP 的 3'-OH 和GMP 的 5'-磷酸之间。2',3'-cGAMP 是在哺乳动物细胞中为响应细胞质中的 DNA 而产生并以高亲和力结合STING，是干扰素-β (IFNβ) 的有效诱导物。

Fields of Application :
2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.

Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)

Note: Products for research use only, not for human use

Description:
2’3’-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. 2’3’-cGAMP is also referred to as “noncanonical“ cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3’3’-cGAMP, 2’3’-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β . Structural and functional studies revealed that noncanonical 2’3’-cGAMP is distinct from the canonical 3’3’-cGAMP produced by bacteria. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP. Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP.