15926423062
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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途范围 | 中间体 |
| 纯度 | 98%% |
| CAS编号 | 213743-31-8 |
| 规格 | 20mg |
| 是否进口 | 否 |
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| 常用名 | RK-24466 | 英文名 | RK-24466 |
|---|---|---|---|
| CAS号 | 213743-31-8 | 分子量 | 370.447 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 605.1±55.0 °C at 760 mmHg |
| 分子式 | C23H22N4O | 熔点 | N/A |
| MSDS | 美版 | 闪点 | 319.7±31.5 °C |
RK-24466 (KIN 001-51) 是一种高效选择性的 Lck 抑制剂; 抑制Lck (64-509) 和LckCD亚型的IC50 值分别为小于1 和2 nM。
Fields of Application :
RK-24466 (KIN 001-51) is a potent and selective Lck inhibitor; inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.
| CAS Number: | 213743-31-8 |
| Purity: | >98% |
| Molecular Weight: | 370.45 |
| Molecular Formula: | C23H22N4O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | RK-24466 ,RK 24466 ,RK24466 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
RK-24466 is selective for Lck over a range of receptor, non-receptor tyrosine kinases and seronine/threonine kinases. RK-24466 are potent inhibitors of IL2 production in Jurkat cells stimulated with anti-CD3 antibody, being at least 100-fold more potent than PP1. RK-24466 displays remarkable cellular selectivity. RK-24466 significantly inhibits both VSMC proliferation and migration. RK-24466 suppresses VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreases the expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 and, the phosphorylation of retinoblastoma protein (pRb).
References:
NC1=C2C(N(C3CCCC3)C=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1
15926423062
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