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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 524923-88-4 |
| 是否进口 | 否 |
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| 常用名 | JNJ-10229570 | 英文名 | JNJ-10229570 |
|---|---|---|---|
| CAS号 | 524923-88-4 | 分子量 | 389.47000 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C22H19N3O2S | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
JNJ-10229570 是肾上腺皮质受体 1 (MC1R) 和肾上腺皮质受体 5 (MC5R) 的拮抗剂，可抑制皮脂腺分化和皮质特异性脂质的产生，其抑制 125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的 IC50 值分别为 270 nM 和 200 nM。
Fields of Application :
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively.
| CAS Number: | 524923-88-4 |
| Purity: | >98% |
| Molecular Weight: | 389.47 |
| Molecular Formula: | C22H19N3O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | JNJ-10229570; JNJ10229570; JNJ 10229570 |
| Chemical Name: | Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
References:
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