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Tafamidis葡甲胺用途:

Tafamidis meglumine (Fx-1006A) 是一种有效、选择性的 transthyretin (TTR) 稳定剂，对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR，V122I-TTR 的活性相当，EC50 值为 2.7-3.2 μM。Tafamidis meglumine 抑制淀粉样蛋白的生成。

Fields of Application : 
Tafamidis is a novel specific transthyretin (TTR) stabilizer or dissociation inhibitor.

Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)

Note: Products for research use only, not for human use

Description:
Tafamidis is a novel specific transthyretin (TTR) stabilizer or dissociation inhibitor. TTR is a tetramer that is responsible in transporting the retinol-binding protein-vitamin A complex and minimally transporting thyroxine in the blood. In TTR-related disorders such as transthyretin familial amyloid polyneuropathy (TTR-FAP), tetramer dissociation is accelerated that results in unregulated amyloidogenesis and amyloid fibril formation. Eventually the failure of autonomic and peripheral nervous system is induced.

References: 
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