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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1190197-97-7 |
| 是否进口 | 否 |
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| 常用名 | DLIN-KC2-DMA | 英文名 | DLin-KC2-DMA |
|---|---|---|---|
| CAS号 | 1190197-97-7 | 分子量 | 642.09 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C43H79NO2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
DLin-KC2-DMA 是一种可用于siRNA 传递的阳离子/可电离的脂质。
Fields of Application :
DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA.
| CAS Number: | 1190197-97-7 |
| Purity: | >98% |
| Molecular Weight: | 641.61 |
| Molecular Formula: | C43H79NO2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | |
| Chemical Name: | 2,2-dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
DLin-KC2-DMA is useful cationic lipid for siRNA delivery. DLin-KC2-DMA (2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane), and DLin-MC3-DMA, which are 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA (1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane).The ED50 (median effective dose) for LNP containing DLin-MC3-DMA to silence Factor VII in mice and TTR in non-human primates was 0.005 mg/kg and 0.03 mg/kg, respectively.
References:
CN(CCC1OC(CCCCCCCC/C=C\C/C=C\CCCCC)(CCCCCCCC/C=C\C/C=C\CCCCC)OC1)C
