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Lefamulin acetate (BC-3781 acetate) 是一种口服活性抗生素，用于 community-acquired bacterial pneumonia (CABP) 治疗。Lefamulin acetate (BC-3781 acetate) 是第一种用于人体细菌感染的全身治疗的半合成截短侧耳素。Lefamulin acetate (BC-3781 acetate) 通过与 50S 细菌核糖体的肽基转移酶 peptidyl transferase 中心结合来抑制蛋白质合成，从而阻止了转移RNA与肽转移的结合。

Fields of Application : 
Lefamulin acetate is a pleuromutilin antibiotic that is being developed by Nabriva Therapeutics for the treatment of acute bacterial skin and skin-structure infections.

Description:
Lefamulin is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow. Lefamulin acts by binding to the peptidyl transferase center, or PTC, on the bacterial ribosome in such a way that it interferes with the interaction of protein production at two key sites known as the “A” site and the “P” site, resulting in the inhibition of bacterial proteins and the cessation of bacterial growth. Lefamulin’s binding occurs with high affinity, high specificity and at molecular sites that are different than other antibiotic classes. For the detailed information of Lefamulin(BC-3781), the solubility of Lefamulin(BC-3781) in water, the solubility of Lefamulin(BC-3781) in DMSO, the solubility of Lefamulin(BC-3781) in PBS buffer, the animal experiment (test) of  Lefamulin(BC-3781), the cell expriment (test) of Lefamulin(BC-3781), the in vivo, in vitro and clinical trial test of Lefamulin(BC-3781), the EC50, IC50,and affinity,of Lefamulin(BC-3781), For the detailed information of Lefamulin(BC-3781), the solubility of Lefamulin(BC-3781) in water, the solubility of Lefamulin(BC-3781) in DMSO, the solubility of Lefamulin(BC-3781) in PBS buffer, the animal experiment (test) of  Lefamulin(BC-3781), the cell expriment (test) of Lefamulin(BC-3781), the in vivo, in vitro and clinical trial test of Lefamulin(BC-3781), the EC50, IC50,and affinity,of Lefamulin(BC-3781), Please contact DC Chemicals.