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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 252917-06-9 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | CHIR-99021 | 英文名 | CHIR-99021 |
|---|---|---|---|
| CAS号 | 252917-06-9 | 分子量 | 465.338 |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 784.1±70.0 °C at 760 mmHg |
| 分子式 | C22H18Cl2N8 | 熔点 | N/A |
| MSDS | 中文版 美版 | 闪点 | 428.0±35.7 °C |
CHIR-99021是 GSK-3α/β 抑制剂， IC50 分别为 10 nM，6.7 nM。 抑制 GSK-3α/β 比同源物 CDC2 和 ERK2 高 500 倍。
Fields of Application :
CHIR-99021 is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo.
| CAS Number: | 252917-06-9 |
| Purity: | 99% |
| Molecular Weight: | 465.34 |
| Molecular Formula: | C22H18Cl2N8 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | CHIR 99021, CT 99021,CHIR99021,CT-99021 |
| Chemical Name: | 6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile hydrochloride |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 For proliferation is about 10μM. For the detailed information about the solubility of CHIR-99021 (CT99021) in water, the solubility of CHIR-99021 (CT99021) in DMSO, the solubility of CHIR-99021 (CT99021) in PBS buffer, the animal experiment（test） of CHIR-99021 (CT99021),the in vivo,in vitro and clinical trial test of CHIR-99021 (CT99021),the cell experiment（test） of CHIR-99021 (CT99021),the IC50, EC50 and Affinity of CHIR-99021 (CT99021).
CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
