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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1056634-68-4 |
| 是否进口 | 否 |
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Fields of Application :
CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively.
| CAS Number: | 1056634-68-4 |
| Purity: | >98% |
| Molecular Weight: | 414.46 |
| Molecular Formula: | C23H22N6O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | CYT 11387,CYT387 (CYT 387) |
| Chemical Name: | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
CYT387 is an orally-administered, potent, selective inhibitor of the JAK1 and JAK2 kinases, enzymes which have been implicated in a number of disorders including myeloproliferative neoplasms (MPNs), inflammatory diseases and certain cancers. The molecule possesses an excellent selectivity and safety profile with minimal off-target activity, a favorable pharmacokinetic and toxicological profile, and the prospect of limited drug/drug interactions. Data from MPN patient samples demonstrate suppression of JAK enzyme over-activity. CYT387 was developed by Australian biotech company Cytopia Research Pty Ltd, and is now part of the YM BioSciences development program. For the detailed information about the solubility of CYT387 (CYT-387) in water, the solubility of CYT387 (CYT-387) in DMSO, the solubility of CYT387 (CYT-387) in PBS buffer, the animal experiment（test） of CYT387 (CYT-387),the in vivo,in vitro and clinical trial test of CYT387 (CYT-387),the cell experiment（test） of CYT387 (CYT-387),the IC50, EC50 and Affinity of CYT387 (CYT-387).
References:
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