|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 718630-59-2 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
Fields of Application :
PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.
| CAS Number: | 718630-59-2 |
| Purity: | 99% |
| Molecular Weight: | 361.48 |
| Molecular Formula: | C19H31N5O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PHA793887,PHA 793887 |
| Chemical Name: | N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of PHA-793887: PHA-793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. Although toxicity was acceptable at initial dose levels, PHA-793887 was poorly tolerated at doses ≥44 mg/m2. The most frequent events across all dose levels were gastrointestinal or nervous system events. PHA-793887 induces severe, dose-related hepatic toxicity, which was not predicted by pre-clinical models and currently precludes its further clinical development. (source: Cell Cycle. 2011 Mar 15;10(6):963-70.). For the detailed information about the solubility of PHA-793887 in water, the solubility of PHA-793887 in DMSO, the solubility of PHA-793887 in PBS buffer, the animal experiment（test） of PHA-793887,the in vivo,in vitro and clinical trial test of PHA-793887,the cell experiment（test） of PHA-793887,the IC50, EC50 and Affinity of PHA-793887.
References:
C(NC1=NNC2C(C)(C)N(C(C3CCN(C)CC3)=O)CC=21)(=O)CC(C)C
