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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1001350-96-4 |
| 是否进口 | 否 |
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Fields of Application :
BMS-754807 is a potent and reversible inhibitor of IGF-1R/IR family kinases, inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7 nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively.
| CAS Number: | 1001350-96-4 |
| Purity: | 99% |
| Molecular Weight: | 461.49 |
| Molecular Formula: | C23H24FN9O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | BMS-754807,BMS 754807 |
| Chemical Name: | (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of BMS 754807 in water, the solubility of BMS 754807 in DMSO, the solubility of BMS 754807 in PBS buffer, the animal experiment（test） of BMS 754807,the in vivo,in vitro and clinical trial test of BMS 754807,the cell experiment（test） of BMS 754807,the IC50, EC50 and Affinity of BMS 754807.
References:
N(C1N=C(NC2C=C(C3CC3)NN=2)C2=CC=CN2N=1)1CCC[C@]1(C)C(NC1=CC=C(F)N=C1)=O
