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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 587871-26-9 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
Fields of Application :
KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively.
| CAS Number: | 587871-26-9 |
| Purity: | >98% |
| Molecular Weight: | 395.49 |
| Molecular Formula: | C21H17NO3S2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | KU55933, KU 55933 |
| Chemical Name: | 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone.For the detailed information about the solubility of KU-55933 in water, the solubility of KU-55933 in DMSO, the solubility of KU-55933 in PBS buffer, the animal experiment（test） of KU-55933,the in vivo,in vitro and clinical trial test of KU-55933,the cell experiment（test） of KU-55933,the IC50, EC50 and Affinity of KU-55933.
References:
C(N1CCOCC1)1OC(C2=C3C(SC4=C(S3)C=CC=C4)=CC=C2)=CC(=O)C=1
