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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 475207-59-1 |
| 是否进口 | 否 |
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Fields of Application :
Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
| CAS Number: | 475207-59-1 |
| Purity: | 99% |
| Molecular Weight: | 637.03 |
| Molecular Formula: | C21H16ClF3N4O3.C7H8O3S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Bay 43-9006,Bay43-9006 |
| Chemical Name: | 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1) |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Sorafenib tosylate is the tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Sorafenib (BAY-43-9006) in water, the solubility of Sorafenib (BAY-43-9006) in DMSO, the solubility of Sorafenib (BAY-43-9006) in PBS buffer, the animal experiment（test） of Sorafenib (BAY-43-9006),the in vivo,in vitro and clinical trial test of Sorafenib (BAY-43-9006),the cell experiment（test） of Sorafenib (BAY-43-9006),the IC50, EC50 and Affinity of Sorafenib (BAY-43-9006).
References:
C(C(NC)=O)1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1.C(S(O)(=O)=O)1=CC=C(C)C=C1
