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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1415562-82-1 |
| 是否进口 | 否 |
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Fields of Application :
PF-543 is a novel Sphingosine kinase 1 (SphK1, SK1) inhibitor with Ki of 3.6 nM.
| CAS Number: | 1415562-82-1 |
| Purity: | >98% |
| Molecular Weight: | 465.6 |
| Molecular Formula: | C27H31NO4S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PF543, PF 543 |
| Chemical Name: | 2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of PF-543: PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective For SphK1 over the SphK2 iso Form. PF-543 was effective as a potent inhibitor of S1P Formation in whole blood, indicating that the SphK1 iso Form of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful For dissecting specific roles of SphK1-driven S1P signalling. (source: Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.) For the detailed information about the solubility of PF-543 in water, the solubility of PF-543 in DMSO, the solubility of PF-543 in PBS buffer, the animal experiment（test） of PF-543,the in vivo,in vitro and clinical trial test of PF-543,the cell experiment（test） of PF-543,the IC50, EC50 and Affinity of PF-543.
References:
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