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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 950762-95-5 |
| 是否进口 | 否 |
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Fields of Application :
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM.
| CAS Number: | 950762-95-5 |
| Purity: | >98% |
| Molecular Weight: | 296.32 |
| Molecular Formula: | C17H16N2O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PCI34051, PCI 34051 |
| Chemical Name: | 1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
PCI-34051 is a specific inhibitor of HDAC8 with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms. IC50 Value: 10 nM Target: HDAC8 in vitro: PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. Cells defective in T-cell receptor signaling were still sensitive to PCI-34051-induced apoptosis, whereas a phospholipase C-gamma1 (PLCgamma1)-defective line was resistant. HDAC8-inhibitor specifically induces cell death in T-cell-derived lines, which is caspase dependent For the detailed information about the solubility of PCI-34051 in water, the solubility of PCI-34051 in DMSO, the solubility of PCI-34051 in PBS buffer, the animal experiment（test） of PCI-34051,the in vivo,in vitro and clinical trial test of PCI-34051,the cell experiment（test） of PCI-34051,the IC50, EC50 and Affinity of PCI-34051.
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