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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 56396-35-1 |
| 是否进口 | 否 |
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Fields of Application :
UK5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
| CAS Number: | 56396-35-1 |
| Purity: | >98% |
| Molecular Weight: | 288.31 |
| Molecular Formula: | C18H12N2O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PF-1005023; UK5099; UK 5099; PF1005023; PF 1005023 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
UK-5099(PF1005023) is a potent inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC); inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM. IC50 value: 50 nM Target: MCT The trypanosomal pyruvate carrier was found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (Ki = 17 mM) but could be completely blocked by UK5099 (Ki = 49 microM). Inhibition of pyruvate transport resulted in the retention, and concomitant accumulation, of pyruvate within the trypanosomes, causing acidification of the cytosol and osmotic destabilization of the cells. UK-5099 is more powerful inhibitor than alpha-cyano-4-hydroxycinnamate showing 50% inhibition of pyruvate-dependent O2 consumption by rat heart mitochondria at concentrations of 200, 200 and 50 nM respectively. For the detailed information about the solubility of UK-5099 (UK5099 ) in water, the solubility of UK-5099 (UK5099 ) in DMSO, the solubility of UK-5099 (UK5099 ) in PBS buffer, the animal experiment（test） of UK-5099 (UK5099 ),the in vivo,in vitro and clinical trial test of UK-5099 (UK5099 ),the cell experiment（test） of UK-5099 (UK5099 ),the IC50, EC50 and Affinity of UK-5099 (UK5099 ).
References:
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