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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 775304-57-9 |
| 是否进口 | 否 |
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| 常用名 | ATALUREN | 英文名 | Ataluren |
|---|---|---|---|
| CAS号 | 775304-57-9 | 分子量 | 284.242 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 503.7±60.0 °C at 760 mmHg |
| 分子式 | C15H9FN2O3 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 258.4±32.9 °C |
PTC124靶向作用于无义突变，将终止密码子插入到CFTR基因中间。
Fields of Application :
PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM.
| CAS Number: | 775304-57-9 |
| Purity: | >98% |
| Molecular Weight: | 284.24 |
| Molecular Formula: | C15H9FN2O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Ataluren, PTC-124 |
| Chemical Name: | 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Ataluren: Ataluren (PTC124) is an investigational new drug designed to enable the Formation of a functioning protein in patients with genetic disorders due to a nonsense mutation. A nonsense mutation is an alteration in the genetic code that prematurely halts the synthesis of an essential protein. Ataluren is currently being investigated For use in patients with nonsense mutation Duchenne/Becker muscular dystrophy (nmDBMD) and cystic fibrosis (nmCF) . For the detailed information about the solubility of PTC124 (Ataluren) in water, the solubility of PTC124 (Ataluren) in DMSO, the solubility of PTC124 (Ataluren) in PBS buffer, the animal experiment（test） of PTC124 (Ataluren),the in vivo,in vitro and clinical trial test of PTC124 (Ataluren),the cell experiment（test） of PTC124 (Ataluren),the IC50, EC50 and Affinity of PTC124 (Ataluren).
References:
C(O)(=O)C1=CC=CC(C2N=C(C3=CC=CC=C3F)ON=2)=C1
