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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 146426-40-6 |
| 是否进口 | 否 |
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Fields of Application :
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.
| CAS Number: | 146426-40-6 |
| Purity: | 99% |
| Molecular Weight: | 401.84 |
| Molecular Formula: | C21H20ClNO5 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | HMR-1275, L86-8275 |
| Chemical Name: | 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Alvocidib is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Flavopiridol in water, the solubility of Flavopiridol in DMSO, the solubility of Flavopiridol in PBS buffer, the animal experiment（test） of Flavopiridol,the in vivo,in vitro and clinical trial test of Flavopiridol,the cell experiment（test） of Flavopiridol,the IC50, EC50 and Affinity of Flavopiridol.
References:
OC(C=C1O)=C([C@H]2[C@@H](O)CN(C)CC2)C(OC(C3=C(Cl)C=CC=C3)=C4)=C1C4=O
