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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 157716-52-4 |
| 是否进口 | 否 |
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| 常用名 | 哌立福新 | 英文名 | Perifosine |
|---|---|---|---|
| CAS号 | 157716-52-4 | 分子量 | 461.658 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C25H52NO4P | 熔点 | 271-272° (dec) |
| MSDS | 中文版 美版 | 闪点 | N/A |
Perifosine 是一种口服有效的 Akt 抑制剂。Perifosine 对绝大多数细胞具有抗增殖活性，IC50 为 0.6-8.9 μM。
Fields of Application :
Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM.
| CAS Number: | 157716-52-4 |
| Purity: | >98% |
| Molecular Weight: | 461.66 |
| Molecular Formula: | C25H52NO4P |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | KRX0401, KRX 0401 |
| Chemical Name: | Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Perifosine: Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Perifosine (KRX-0401) in water, the solubility of Perifosine (KRX-0401) in DMSO, the solubility of Perifosine (KRX-0401) in PBS buffer, the animal experiment（test） of Perifosine (KRX-0401),the in vivo,in vitro and clinical trial test of Perifosine (KRX-0401),the cell experiment（test） of Perifosine (KRX-0401),the IC50, EC50 and Affinity of Perifosine (KRX-0401), please contact DC Chemicals.
