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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 219580-11-7 |
| 是否进口 | 否 |
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| 常用名 | PD173074 | 英文名 | PD173074 |
|---|---|---|---|
| CAS号 | 219580-11-7 | 分子量 | 523.670 |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C28H41N7O3 | 熔点 | 82-85°C |
| MSDS | 中文版 美版 | 闪点 | N/A |
PD173074 是一种有效的 FGFR1 抑制剂，IC50 为 25 nM；同时抑制 VEGFR2 的活性，IC50 值为 100-200 nM，对 FGFR1 的活性是 PDGFR 和 c-Src 的1000多倍。
Fields of Application :
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.
| CAS Number: | 219580-11-7 |
| Purity: | >98% |
| Molecular Weight: | 523.67 |
| Molecular Formula: | C28H41N7O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PD173074, PD 173074 |
| Chemical Name: | 1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM For FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM For EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. For the detailed information about the solubility of PD-173074 in water, the solubility of PD-173074 in DMSO, the solubility of PD-173074 in PBS buffer, the animal experiment（test） of PD-173074,the in vivo,in vitro and clinical trial test of PD-173074,the cell experiment（test） of PD-173074,the IC50, EC50 and Affinity of PD-173074, please contact DC Chemicals.
