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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 79183-19-0 |
| 是否进口 | 否 |
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| 常用名 | MDK83190 | 英文名 | Apoptosis Activator 2 |
|---|---|---|---|
| CAS号 | 79183-19-0 | 分子量 | 306.143 |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 470.6±55.0 °C at 760 mmHg |
| 分子式 | C15H9Cl2NO2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 238.4±31.5 °C |
Apoptosis Activator 2是细胞凋亡有效激活剂，能促进procaspase-9的加工并活化caspase-3。
Fields of Application :
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
| CAS Number: | 79183-19-0 |
| Purity: | >98% |
| Molecular Weight: | 306.14 |
| Molecular Formula: | C15H9Cl2NO2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | |
| Chemical Name: | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM For Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3. For the detailed information about the solubility of Apoptosis Activator 2 in water, the solubility of Apoptosis Activator 2 in DMSO, the solubility of Apoptosis Activator 2 in PBS buffer, the animal experiment（test） of Apoptosis Activator 2 , the in vivo,in vitro and clinical trial test of Apoptosis Activator 2 , the cell experiment（test） of Apoptosis Activator 2 , the IC50, EC50 and Affinity of Apoptosis Activator 2 , please contact DC Chemicals.
