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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 327036-89-5 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | TDZD-8 | 英文名 | TDZD-8 |
|---|---|---|---|
| CAS号 | 327036-89-5 | 分子量 | 222.264 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 335.5±35.0 °C at 760 mmHg |
| 分子式 | C10H10N2O2S | 熔点 | 63-64.4oC |
| MSDS | 中文版 美版 | 闪点 | 156.7±25.9 °C |
TDZD-8 是 GSK-3β 的抑制剂，IC50 为 2 μM；TDZD-8 对 Cdk-1/cyclin?B，CK-II，PKA 和 PKC 的作用较弱，IC50 值均 >100 μM。
Fields of Application :
TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM.
| CAS Number: | 327036-89-5 |
| Purity: | >98% |
| Molecular Weight: | 222.26 |
| Molecular Formula: | C10H10N2O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | TDZD8, TDZD 8 |
| Chemical Name: | 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of TDZD-8: TDZD-8 is a serine/threonine glycogen synthase kinase 3beta (GSK-3beta) inhibitor. GSK-3beta is abundant in the central nervous system, particularly in the hippocampus, and plays a pivotal role in the pathophysiology of a number of diseases, including neurodegeneration. TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. TDZD-8 decreased proliferation and induced apoptosis of GL261 glioblastoma cells in vitro, delayed tumor growth in vivo, and augmented animal survival. These effects were associated with an early activation of extracellular signal-regulated kinase (ERK) pathway and increased expression of EGR-1 and p21 genes. Treatment of glioblastoma stem cells with TDZD-8 resulted in an inhibition of proliferation and self-renewal of these cells. For the detailed information about the solubility of TDZD-8 in water, the solubility of TDZD-8 in DMSO, the solubility of TDZD-8 in PBS buffer, the animal experiment（test） of TDZD-8,the in vivo,in vitro and clinical trial test of TDZD-8,the cell experiment（test） of TDZD-8,the IC50, EC50 and Affinity of TDZD-8, please contact DC Chemicals.
