|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 405169-16-6 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 多韦替尼 | 英文名 | Dovitinib |
|---|---|---|---|
| CAS号 | 405169-16-6 | 分子量 | 392.429 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C21H21FN6O | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
Dovitinib是多靶点的酪氨酸激酶抑制剂，抑制FLT3，c-Kit，FGFR1/3，VEGFR1/2/3 和 PDGFRα/β 的 IC50 值分别为1，2，8/9，10/13/8，27/210 nM。
Fields of Application :
Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.
| CAS Number: | 405169-16-6 |
| Purity: | 99% |
| Molecular Weight: | 392.43 |
| Molecular Formula: | C21H21FN6O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | CHIR-258,CHIR 258 |
| Chemical Name: | 1-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
CHIR-265 is an orally bioavailable small molecule with potential antineoplastic activity.CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of CHIR258 in water, the solubility of CHIR258 in DMSO, the solubility of CHIR258 in PBS buffer, the animal experiment（test） of CHIR258,the in vivo,in vitro and clinical trial test of CHIR258,the cell experiment（test） of CHIR258,the IC50, EC50 and Affinity of CHIR258, please contact DC Chemicals.
