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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1208319-26-9 |
| 是否进口 | 否 |
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| 常用名 | 奥拉替尼 | 英文名 | Oclacitinib |
|---|---|---|---|
| CAS号 | 1208319-26-9 | 分子量 | 337.440 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C15H23N5O2S | 熔点 | N/A |
| MSDS | N/A | 闪点 | N/A |
Oclacitinib 是一种新型 JAK 抑制剂。Oclacitinib 抑制 JAK1 *，IC50 为 10 nM。
Fields of Application :
Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy.
| CAS Number: | 1208319-26-9 |
| Purity: | >98% |
| Molecular Weight: | 337.16 |
| Molecular Formula: | C15H23N5O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | PF03394197, PF 03394197 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM). IC50 value: 10 nM (JAK1) Target: JAKs in vitro: Oclacitinib inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm) . in vivo: Dogs were randomized to receive either oclacitinib (0.4-0.6 mg/kg twice daily for 14 days and then once daily for up to 112 days) or an excipient-matched placebo .Dogs were randomized to either oclacitinib at 0.4-0.6 mg/kg orally twice daily or an excipient-matched placebo. An enhanced 10 cm visual analog scale (VAS) was used by the owners to assess the severity of pruritus from day 0 to 7 and by veterinarians to assess the severity of dermatitis on days 0 and 7. Dogs could remain on the study for 28 days . For the detailed information of PF-03394197, the solubility of PF-03394197 in water, the solubility of PF-03394197 in DMSO, the solubility of PF-03394197 in PBS buffer, the animal experiment (test) of PF-03394197, the cell expriment (test) of PF-03394197, the in vivo, in vitro and clinical trial test of PF-03394197, the EC50, IC50,and Affinity of PF-03394197, Please contact DC Chemicals.
