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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1402836-58-1 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | IDO-IN-7 | 英文名 | NLG919 |
|---|---|---|---|
| CAS号 | 1402836-58-1 | 分子量 | 282.380 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 524.6±33.0 °C at 760 mmHg |
| 分子式 | C18H22N2O | 熔点 | N/A |
| MSDS | N/A | 闪点 | 271.1±25.4 °C |
IDO-IN-7 (NLG-919 analogue) 是一种有效的 IDO1 抑制剂, IC50为 38 nM。
Fields of Application :
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
| CAS Number: | 1402836-58-1 |
| Purity: | >99% |
| Molecular Weight: | 282.38 |
| Molecular Formula: | C18H22N2O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | NLG-919, NLG 919, IDO INHIBITOR,GDC-0919,GDC 0919,GDC0919 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
In vitro: NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM. In vivo:In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA. For the detailed information of NLG919, the solubility of NLG919 in water, the solubility of NLG919 in DMSO, the solubility of NLG919 in PBS buffer, the animal experiment (test) of NLG919, the cell expriment (test) of NLG919, the in vivo, in vitro and clinical trial test of NLG919, the EC50, IC50,and Affinity of NLG919, Please contact DC Chemicals.
