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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 170151-24-3 |
| 是否进口 | 否 |
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| 常用名 | 内匹司他盐酸盐 | 英文名 | Nepicastat (hydrochloride) |
|---|---|---|---|
| CAS号 | 170151-24-3 | 分子量 | 331.812 |
| 密度 | N/A | 沸点 | N/A |
| 分子式 | C14H16ClF2N3S | 熔点 | N/A |
| MSDS | 中文版 美版 | 闪点 | N/A |
Nepicastat(SYN117; RS-25560-197)盐酸盐是多巴胺_beta_-羟化酶高效抑制剂，对牛源和人源巴胺_beta_-羟化酶的IC50值分别为8.5和9.0nM。
Fields of Application :
Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
| CAS Number: | 170151-24-3 |
| Purity: | >98% |
| Molecular Weight: | 331.81 |
| Molecular Formula: | C14H15F2N3S.HCl |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | SYN117 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Nepicastat (SYN117; RS-25560-197) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase) Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such. For the detailed information of Nepicastat HCl (SYN-117), the solubility of Nepicastat HCl (SYN-117) in water, the solubility of Nepicastat HCl (SYN-117) in DMSO, the solubility of Nepicastat HCl (SYN-117) in PBS buffer, the animal experiment (test) of Nepicastat HCl (SYN-117), the cell expriment (test) of Nepicastat HCl (SYN-117), the in vivo, in vitro and clinical trial test of Nepicastat HCl (SYN-117), the EC50, IC50,and Affinity of Nepicastat HCl (SYN-117), Please contact DC Chemicals.
