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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 4311-88-0 |
| 是否进口 | 否 |
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| 常用名 | Necrostatin-1 | 英文名 | Necrostatin-1 |
|---|---|---|---|
| CAS号 | 4311-88-0 | 分子量 | 259.327 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 441.9±37.0 °C at 760 mmHg |
| 分子式 | C13H13N3OS | 熔点 | 151oC |
| MSDS | 中文版 美版 | 闪点 | 221.1±26.5 °C |
Necrostatin-1是一种有效，选择性和可渗透细胞的坏死性凋亡 (necroptosis) 抑制剂，在Jurkat细胞中的 EC50 为490 nM。它通过抑制坏死性凋亡途径中的死亡域受体激酶RIP (RIP1) 起作用。
Fields of Application :
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
| CAS Number: | 4311-88-0 |
| Purity: | >98% |
| Molecular Weight: | 259.33 |
| Molecular Formula: | C13H13N3OS |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Necrostatin1, Necrostatin 1 |
| Chemical Name: | 4-Imidazolidinone, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Necrostatin-1 is an inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade. For the detailed information about the solubility of Necrostatin-1 in water, the solubility of Necrostatin-1 in DMSO, the solubility of Necrostatin-1 in PBS buffer, the animal experiment（test） of Necrostatin-1,the in vivo,in vitro and clinical trial test of Necrostatin-1,the cell experiment（test） of Necrostatin-1,the IC50, EC50 and Affinity of Necrostatin-1, please contact DC Chemicals.
