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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 302962-49-8 |
| 是否进口 | 否 |
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| 常用名 | 达沙替尼 | 英文名 | Dasatinib |
|---|---|---|---|
| CAS号 | 302962-49-8 | 分子量 | 488.005 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A |
| 分子式 | C22H26ClN7O2S | 熔点 | 275-286°C |
| MSDS | N/A | 闪点 | N/A |
Dasatinib (BMS-354825)是 Bcr-Abl 和 Src 家族酪氨酸激酶抑制剂，抑制Abl， Src，c-Kit和c-KitD816V 的 IC50 分别为0.6，0.8，79和37 nM。
Fields of Application :
Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.5 nM and 79 nM, respectively.
| CAS Number: | 302962-49-8 |
| Purity: | >98% |
| Molecular Weight: | 488.01 |
| Molecular Formula: | C22H26ClN7O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Sprycel,BMS354825,Dasatinib (BMS 354825) |
| Chemical Name: | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Dasatinib: Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity For the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic Forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Dasatinib (BMS-354825) in water, the solubility of Dasatinib (BMS-354825) in DMSO, the solubility of Dasatinib (BMS-354825) in PBS buffer, the animal experiment（test） of Dasatinib (BMS-354825),the in vivo,in vitro and clinical trial test of Dasatinib (BMS-354825),the cell experiment（test） of Dasatinib (BMS-354825),the IC50, EC50 and Affinity of Dasatinib (BMS-354825), please contact DC Chemicals.
