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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 184475-35-2 |
| 是否进口 | 否 |
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| 常用名 | 吉非替尼 | 英文名 | Gefitinib |
|---|---|---|---|
| CAS号 | 184475-35-2 | 分子量 | 446.902 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 586.8±50.0 °C at 760 mmHg |
| 分子式 | C22H24ClFN4O3 | 熔点 | 119-1200C |
| MSDS | N/A | 闪点 | 308.7±30.1 °C |
Gefitinib 是一种有效的表皮生长因子受体 (EGFR) 抑制剂，在 NR6wtEGFR 细胞中 IC50 值为 2-37 nM。
Fields of Application :
Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
| CAS Number: | 184475-35-2 |
| Purity: | 99% |
| Molecular Weight: | 446.9 |
| Molecular Formula: | C22H24ClFN4O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | ZD-1839,ZD 1839 |
| Chemical Name: | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of gefitinib: Gefitinib is an anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. Gefitinib (INN) (Iressa) is a drug used in the treatment of certain types of cancer. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts a growth factor in cancer cells. It is marketed by AstraZeneca and Teva. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of Gefitinib (ZD1839) in water, the solubility of Gefitinib (ZD1839) in DMSO, the solubility of Gefitinib (ZD1839) in PBS buffer, the animal experiment（test） of Gefitinib (ZD1839),the in vivo,in vitro and clinical trial test of Gefitinib (ZD1839),the cell experiment（test） of Gefitinib (ZD1839),the IC50, EC50 and Affinity of Gefitinib (ZD1839), please contact DC Chemicals.
