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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 503468-95-9 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | KU-57788 | 英文名 | NU7441 |
|---|---|---|---|
| CAS号 | 503468-95-9 | 分子量 | 413.488 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 646.9±55.0 °C at 760 mmHg |
| 分子式 | C25H19NO3S | 熔点 | N/A |
| MSDS | N/A | 闪点 | 345.0±31.5 °C |
KU-57788 是一种有效的，选择性的 DNA-PK 抑制剂，IC50 值为 13 nM；同时能够激活 CRISPR/Cas9。
Fields of Application :
NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM.
| CAS Number: | 503468-95-9 |
| Purity: | >98% |
| Molecular Weight: | 413.49 |
| Molecular Formula: | C25H19NO3S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | NU7441，KU57788,NU 7441 (KU 57788) |
| Chemical Name: | 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin and etoposide in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.
