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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1001264-89-6 |
| 是否进口 | 否 |
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| 常用名 | Ipatasertib | 英文名 | GDC-0068 |
|---|---|---|---|
| CAS号 | 1001264-89-6 | 分子量 | 457.996 |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 669.4±55.0 °C at 760 mmHg |
| 分子式 | C24H32ClN5O2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 358.7±31.5 °C |
Ipatasertib (GDC-0068) 是一种选择性，竞争性的 pan-Akt 抑制剂，抑制 Akt1，Akt2，Akt3 的 IC50 分别为 5，18，8 nM。
Fields of Application :
GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively.
| CAS Number: | 1001264-89-6 |
| Purity: | >98% |
| Molecular Weight: | 458 |
| Molecular Formula: | C24H32ClN5O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | GDC0068,GDC 0068,GDC-0068 |
| Chemical Name: | (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of GDC-0068: GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of GDC-0068 in water, the solubility of GDC-0068 in DMSO, the solubility of GDC-0068 in PBS buffer, the animal experiment（test） of GDC-0068,the in vivo,in vitro and clinical trial test of GDC-0068,the cell experiment（test） of GDC-0068,the IC50, EC50 and Affinity of GDC-0068, please contact DC Chemicals.
