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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 872573-93-8 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮 | 英文名 | RO-3306 |
|---|---|---|---|
| CAS号 | 872573-93-8 | 分子量 | 351.445 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 569.1±60.0 °C at 760 mmHg |
| 分子式 | C18H13N3OS2 | 熔点 | N/A |
| MSDS | 美版 | 闪点 | 298.0±32.9 °C |
Ro-3306 是一种有效，选择性的 CDK1 抑制剂，对 CDK1，CDK1/cyclin B1 和 CDK2/cyclin E 的 Ki 值为分别为 20 nM，35 nM 和 340 nM。
Fields of Application :
Ro-3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D.
| CAS Number: | 872573-93-8 |
| Purity: | >98% |
| Molecular Weight: | 351.4 |
| Molecular Formula: | C18H13N3OS2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | RO3306,RO 3306 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Ro-3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D. Ro-3306 also inhibited CDK1/cyclin A complexes with Ki of 110 nM. In full agreement with this model, treatment of proliferating human cancer cells (HCT116, SW480, and HeLa) with RO-3306 for 20 h led to a complete block of the cell cycle in the G2/M phase. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 acts cooperatively with Nutlin-3 to induce mitochondrial apoptosis in a cell cycle-independent fashion. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. The GV-arrest effect of RO-3306 was reversible: when RO-3306-arrested COCs were subsequently cultured for 24h in the absence of RO-3306, 76.19 ± 2.68% of these oocytes reached the MII stage after 44 h of in vitro maturation, a rate similar to that of non-treated control oocytes (79.08 ± 3.23%). Furthermore, RO-3306-treated oocytes transferred to drug-free media did not differ significantly from controls (P>0.05) with respect to cleavage and blastocyst formation upon parthenogenetic activation. For the detailed information about the solubility of RO-3306 in water, the solubility of RO-3306 in DMSO, the solubility of RO-3306 in PBS buffer, the animal experiment（test） of RO-3306,the in vivo,in vitro and clinical trial test of RO-3306,the cell experiment（test） of RO-3306,the IC50, EC50 and Affinity of RO-3306, please contact DC Chemicals.
