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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1222998-36-8 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
| 常用名 | 都灵1 | 英文名 | Torin 1 |
|---|---|---|---|
| CAS号 | 1222998-36-8 | 分子量 | 607.624 |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 817.2±65.0 °C at 760 mmHg |
| 分子式 | C35H28F3N5O2 | 熔点 | N/A |
| MSDS | N/A | 闪点 | 448.0±34.3 °C |
Torin 1 是一种有效的 mTOR 抑制剂，IC50 为 3 nM。Torin 1 抑制 mTORC1/2 复合物，IC50 值在 2 和 10 nM 之间。
Fields of Application :
Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
| CAS Number: | 1222998-36-8 |
| Purity: | >98% |
| Molecular Weight: | 607.62 |
| Molecular Formula: | C35H28F3N5O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | Torin-1,Torin 1 |
| Chemical Name: | Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM; exhibits 1000-fold selectivity for mTOR than PI3K. IC50 value: 2 nM/10 nM(mTORC1/2) Target: mTORC1/2 in vitro: respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases . In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON . in vivo: Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues . For the detailed information about the solubility of Torin 1 in water, the solubility of Torin 1 in DMSO, the solubility of Torin 1 in PBS buffer, the animal experiment（test） of Torin 1,the in vivo,in vitro and clinical trial test of Torin 1,the cell experiment（test） of Torin 1,the IC50, EC50 and Affinity of Torin 1.
References:
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