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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 1232410-49-9 |
| 是否进口 | 否 |
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Fields of Application :
VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively.
| CAS Number: | 1232410-49-9 |
| Purity: | >98% |
| Molecular Weight: | 368.41 |
| Molecular Formula: | C18H16N4O3S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | VE821,VE 821 |
| Chemical Name: | 2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl- |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of VE-821: VE-821 is the first highly selective and potent ATR inhibitor. VE-821 inhibited radiation- and gemcitabine-induced phosphorylation of Chk1, confirming inhibition of ATR signaling. Consistently, VE-821 significantly enhanced the sensitivity of PSN-1, MiaPaCa-2 and primary PancM pancreatic cancer cells to radiation and gemcitabine under both normoxic and hypoxic conditions. ATR inhibition by VE-821 led to inhibition of radiation-induced G 2/M arrest in cancer cells. For the detailed information about the solubility of VE-821 in water, the solubility of VE-821 in DMSO, the solubility of VE-821 in PBS buffer, the animal experiment（test） of VE-821,the in vivo,in vitro and clinical trial test of VE-821,the cell experiment（test） of VE-821,the IC50, EC50 and Affinity of VE-821.
References:
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