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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 289499-45-2 |
| 是否进口 | 否 |
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| 常用名 | 卡纽替尼二盐酸盐 | 英文名 | Canertinib dihydrochloride |
|---|---|---|---|
| CAS号 | 289499-45-2 | 分子量 | 558.860 |
| 密度 | 1.355g/cm3 | 沸点 | 691oC at 760mmHg |
| 分子式 | C24H27Cl3FN5O3 | 熔点 | N/A |
| MSDS | 中文版 美版 | 闪点 | 371.7oC |
Canertinib dihydrochloride (CI-1033;PD-183805) 是有效地，不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自身磷酸化的 IC50 值分别为7.4和9 nM。
Fields of Application :
Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities.
| CAS Number: | 289499-45-2 |
| Purity: | >98% |
| Molecular Weight: | 558.86 |
| Molecular Formula: | C24H27Cl3FN5O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Canertinib dihydrochloride. Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) For the detailed information about the solubility of Canertinib dihydrochloride in water, the solubility of Canertinib dihydrochloride in DMSO, the solubility of Canertinib dihydrochloride in PBS buffer, the animal experiment（test） of Canertinib dihydrochloride,the in vivo,in vitro and clinical trial test of Canertinib dihydrochloride,the cell experiment（test） of Canertinib dihydrochloride,the IC50, EC50 and Affinity of Canertinib dihydrochloride.
References:
C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
