|
| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 915769-50-5 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
Fields of Application :
Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.
| CAS Number: | 915769-50-5 |
| Purity: | 99% |
| Molecular Weight: | 500.53 |
| Molecular Formula: | C21H21FN6O.C3H6O3.H2O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | TKI258,CHIR258,Dovitinib (TKI 258,CHIR 258) |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor. Dovitinib inhibited proliferation of ZNF198-FGFR1 and BCR-FGFR1 trans Formed Ba/F3 cells with IC50 values of 150 nM and 90 nM, respectively. The phosphorylation of each fusion gene, ERK, and STAT5 was inhibited as well at the same time. Dovitinib also inhibited proliferation of the FGFR1OP2-FGFR1-positive KG1 and KG1A cell lines and induced apoptosis. Furthermore, dovitinib significantly inhibited the growth of primary cells from 8p11 myeloproliferative syndrome (EMS) patients dose-dependently. For the detailed information about the solubility of Dovitinib (TKI-258, CHIR-258) in water, the solubility of Dovitinib (TKI-258, CHIR-258) in DMSO, the solubility of Dovitinib (TKI-258, CHIR-258) in PBS buffer, the animal experiment（test） of Dovitinib (TKI-258, CHIR-258),the in vivo,in vitro and clinical trial test of Dovitinib (TKI-258, CHIR-258),the cell experiment（test） of Dovitinib (TKI-258, CHIR-258),the IC50, EC50 and Affinity of Dovitinib (TKI-258, CHIR-258).
References:
N1C2=C(C(F)=CC=C2)C(N)=C(C2NC3=CC(N4CCN(C)CC4)=CC=C3N=2)C1=O.C(O)(=O)C(O)C
