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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 867160-71-2 |
| 是否进口 | 否 |
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Fields of Application :
OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.
| CAS Number: | 867160-71-2 |
| Purity: | 99% |
| Molecular Weight: | 421.49 |
| Molecular Formula: | C26H23N5O |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | OSI 906,OSI906 |
| Chemical Name: | (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Linsitinib (OSI-906): Linsitinib (OSI-906) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic trans Formation, and suppresses apoptosis. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). OSI-906 is currently developed by OSI Pharmaceuticals, Inc. see . For the detailed information about the solubility of OSI-906 in water, the solubility of OSI-906 in DMSO, the solubility of OSI-906 in PBS buffer, the animal experiment（test） of OSI-906,the in vivo,in vitro and clinical trial test of OSI-906,the cell experiment（test） of OSI-906,the IC50, EC50 and Affinity of OSI-906.
References:
CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
