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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 763113-22-0 |
| 是否进口 | 否 |
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Fields of Application :
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively.
| CAS Number: | 763113-22-0 |
| Purity: | >99% |
| Molecular Weight: | 434.46 |
| Molecular Formula: | C24H23FN4O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | AZD2281; KU-0059436; KU0059436; AZD-2281; KU0059436; AZD 2281 |
| Chemical Name: | 4-(3-(1-(cyclopropanecarbonyl)piperazine-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Olaparib (AZD-2281) is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) . For the detailed information about the solubility of AZD-2281 Olaprib in water, the solubility of AZD-2281 Olaprib in DMSO, the solubility of AZD-2281 Olaprib in PBS buffer, the animal experiment（test） of AZD-2281 Olaprib,the in vivo,in vitro and clinical trial test of AZD-2281 Olaprib,the cell experiment（test） of AZD-2281 Olaprib,the IC50, EC50 and Affinity of AZD-2281 Olaprib.
References:
C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
