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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 847559-80-2 |
| 是否进口 | 否 |
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Fields of Application :
NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM.
| CAS Number: | 847559-80-2 |
| Purity: | 99% |
| Molecular Weight: | 480.41 |
| Molecular Formula: | C21H23Cl2N5O2S |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | VER-82576,NVP BEP800 |
| Chemical Name: | 2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 showed activity against a panel of human tumor cell lines and primary human xenografts in vitro at nanomolar concentrations. In A375 melanoma and BT-474 breast cancer cell lines, NVP-BEP800 induced client protein degradation (including ErbB2, B-Raf(V600E), Raf-1, and Akt) and Hsp70 induction. Oral administration of NVP-BEP800 was well tolerated and induced robust antitumor responses in tumor xenograft models, including regression in the BT-474 breast cancer model. In these tumor models, NVP-BEP800 modulated Hsp90 client proteins and downstream signaling pathways at doses causing antitumor activity. NVP-BEP800 showed in vivo activity in a variety of dosing regimens covering daily to weekly schedules, potentially providing a high degree of flexibility in dose and schedule within the clinical setting. Overall, given the mechanism of action, preclinical activity profile, tolerability, and pharmaceutical properties, NVP-BEP800 is an exciting new oral Hsp90 inhibitor warranting further development. (source: Mol Cancer Ther; 2010, 9(4); 906-19.) For the detailed information about the solubility of NVP-BEP800 in water, the solubility of NVP-BEP800 in DMSO, the solubility of NVP-BEP800 in PBS buffer, the animal experiment（test） of NVP-BEP800,the in vivo,in vitro and clinical trial test of NVP-BEP800,the cell experiment（test） of NVP-BEP800,the IC50, EC50 and Affinity of NVP-BEP800.
References:
C(N)1=NC(C2=CC(OCCN3CCCC3)=C(Cl)C=C2Cl)=C2C=C(C(NCC)=O)SC2=N1
