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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 827318-97-8 |
| 是否进口 | 否 |
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Fields of Application :
Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.
| CAS Number: | 827318-97-8 |
| Purity: | 99% |
| Molecular Weight: | 474.55 |
| Molecular Formula: | C26H30N6O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | N/A |
| Chemical Name: | (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Danusertib: Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA-739358 binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) . For the detailed information about the solubility of PHA-739358 danusertib in water, the solubility of PHA-739358 danusertib in DMSO, the solubility of PHA-739358 danusertib in PBS buffer, the animal experiment（test） of PHA-739358 danusertib,the in vivo,in vitro and clinical trial test of PHA-739358 danusertib,the cell experiment（test） of PHA-739358 danusertib,the IC50, EC50 and Affinity of PHA-739358 danusertib.
References:
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