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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 873054-44-5 |
| 是否进口 | 否 |
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Fields of Application :
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
| CAS Number: | 873054-44-5 |
| Purity: | >99% |
| Molecular Weight: | 392.49 |
| Molecular Formula: | C24H28N2O3 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | vx770 |
| Chemical Name: | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Description of Ivacaftor: Ivacaftor (VX-770) is an experimental drug candidate For the treatment of cystic fibrosis, currently under development by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. The drug is designed to be effective in patients that have the G551D mutation in the defective protein that causes the disease. G551D, meaning that the amino acid glycine in position 551 is substituted with aspartic acid, is only found in a small percentage of cystic fibrosis patients. The drug is currently in Phase 3 clinical trials and has showed promising results For this subset of patients. Cystic fibrosis is caused by a defect in a protein, cystic fibrosis transmembrane conductance regulator, which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. VX-770 potentiates the effect of the defective protein to restore a more normal function. For the detailed information about the solubility of Ivacaftor (VX-770) in water, the solubility of Ivacaftor (VX-770) in DMSO, the solubility of Ivacaftor (VX-770) in PBS buffer, the animal experiment（test） of Ivacaftor (VX-770),the in vivo,in vitro and clinical trial test of Ivacaftor (VX-770),the cell experiment（test） of Ivacaftor (VX-770),the IC50, EC50 and Affinity of Ivacaftor (VX-770).
References:
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