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| 产地 | 中国 |
| 品牌 | Chemstan |
| 货号 | LC-01 |
| 用途 | 中间体 |
| 包装规格 | 20mg |
| 纯度 | 98%% |
| CAS编号 | 934660-93-2 |
| 是否进口 | 否 |
联合知名大学科研院所及企业开发药食两用植物标准品和天然植物有效单体，主打中药对照品/标准品/天然植物有效单体，小分子化合物库，药物杂质。所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。
Fields of Application :
GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway.
| CAS Number: | 934660-93-2 |
| Purity: | purity:>98% |
| Molecular Weight: | 531.31 |
| Molecular Formula: | C21H21F3IN3O2 |
Quality Control: HPLC、NMR、 LC/MS(Please contact us to get the QC report)
| Synonyms: | xl-518,GDC 0973 (XL518),Cobimetinib,GDC0973,XL-518,XL 518,GDC 0973 |
| Chemical Name: | |
| Storage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
Note: Products for research use only, not for human use
Description:
Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). The combination of GDC-0973 with the PI3K inhibitor GDC-0941 resulted in combination efficacy in vitro and in vivo via induction of biomarkers associated with apoptosis, including Bcl-2 family proapoptotic regulators. The population rate constants associated with tumor growth inhibition for GDC-0973 and GDC-0941 were 0.00102 and 0000651 μM(-1) h(-1), respectively. Using the model based on single-agent and QD combination efficacy data, simulations adequately described the tumor growth from the Q3D combination regimen. Following single doses of GDC-0973, estimated in vivo IC(50) values of %pERK decrease based on tumor concentrations in xenograft mice were 0.78 (WM-266-4) and 0.52 μmol/L (A375).For the detailed information about the solubility of GDC-0973 (XL518) in water, the solubility of GDC-0973 (XL518) in DMSO, the solubility of GDC-0973 (XL518) in PBS buffer, the animal experiment（test） of GDC-0973 (XL518), the in vivo,in vitro and clinical trial test of GDC-0973 (XL518), the cell experiment（test） of GDC-0973 (XL518), the IC50, EC50 and Affinity of GDC-0973 (XL518) .
References:
C(C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F)(N1CC(O)([C@H]2CCCCN2)C1)=O
